Growth Hormone Receptor antibody (AA 25-650)

Catalog No. ABIN7995514

The Rabbit Polyclonal anti-Growth Hormone Receptor antibody is suitable to detect Growth Hormone Receptor in samples from Mouse and Rat. It has been validated for WB, ELISA and FACS.

Quick Overview for Growth Hormone Receptor antibody (AA 25-650) (ABIN7995514)

Target: Growth Hormone Receptor (GHR)

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Growth Hormone Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Grade: Carrier-free

Product Details anti-Growth Hormone Receptor Antibody

Binding Specificity: AA 25-650

Purpose: Anti-Growth hormone receptor/GHR Antibody

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Growth hormone receptor/GHR.Antibody-1. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Growth hormone receptor/GHR recombinant protein (Position: T25-Q650).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Mouse, Rat Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Mouse, Rat ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Growth Hormone Receptor

Target: Growth Hormone Receptor (GHR)

Alternative Name: Ghr

Background:

Background: Growth hormone receptor is a protein that in humans is encoded by the GHR gene. It is mapped to 15 A1, 15 1.84 cM. This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.

Gene Full Name: growth hormone receptor

Molecular Weight: 130 kDa

Gene ID: 14600

UniProt: P16882

Pathways: NF-kappaB Signaling, JAK-STAT Signaling, Response to Growth Hormone Stimulus