GCH1 antibody (AA 1-250) (FITC)

Catalog No. ABIN7995564

This Rabbit Polyclonal antibody specifically detects GCH1 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for GCH1 antibody (AA 1-250) (FITC) (ABIN7995564)

Target: GCH1 (GTP Cyclohydrolase 1 (GCH1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GCH1 antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Product Details anti-GCH1 Antibody (FITC)

Binding Specificity: AA 1-250

Purpose: Anti-GCH1 Antibody FITC Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human GCH1 shares 89.2%,92.5% amino acid (aa) sequence identity with mouse,rat GCH1,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human GCH1 recombinant protein (Position: M1-S250). Human GCH1 shares 89.2% and 92.5% amino acid (aa) sequence identity with mouse and rat GCH1, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for GCH1

Target: GCH1 (GTP Cyclohydrolase 1 (GCH1))

Alternative Name: GCH1

Background:

Background: This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described, however, not all variants give rise to a functional enzyme.

Gene Full Name: GTP cyclohydrolase 1

Gene ID: 2643

UniProt: P30793