GUCY2D antibody (AA 65-1103) (Biotin)

Catalog No. ABIN7995867

This Rabbit Polyclonal antibody specifically detects GUCY2D in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for GUCY2D antibody (AA 65-1103) (Biotin) (ABIN7995867)

Target: GUCY2D (Guanylate Cyclase 2D, Membrane (Retina-Specific) (GUCY2D))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GUCY2D antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-GUCY2D Antibody (Biotin)

Binding Specificity: AA 65-1103

Purpose: Anti-GUCY2D Antibody Biotin Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human GUCY2D recombinant protein (Position: D65-S1103).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for GUCY2D

Target: GUCY2D (Guanylate Cyclase 2D, Membrane (Retina-Specific) (GUCY2D))

Alternative Name: GUCY2D

Background:

Background: This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases.

Gene Full Name: guanylate cyclase 2D, retinal

Gene ID: 3000

UniProt: Q02846

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction