HCK antibody (AA 14-501) (Fluoro550)

Catalog No. ABIN7996960

The Rabbit Polyclonal anti-HCK antibody is suitable to detect HCK in samples from Human and Rat. It has been validated for FACS.

Quick Overview for HCK antibody (AA 14-501) (Fluoro550) (ABIN7996960)

Target: HCK (Hemopoietic Cell Kinase (HCK))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HCK antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-HCK Antibody (Fluoro550)

Binding Specificity: AA 14-501

Purpose: Anti-HCK Antibody Fluoro550 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human HCK shares 89.2%,88.7% amino acid (aa) sequence identity with mouse,rat HCK,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human HCK recombinant protein (Position: R14-R501). Human HCK shares 89.2% and 88.7% amino acid (aa) sequence identity with mouse and rat HCK, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for HCK

Target: HCK (Hemopoietic Cell Kinase (HCK))

Alternative Name: HCK

Background:

Background: The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon.

Gene Full Name: HCK proto-oncogene, Src family tyrosine kinase

Gene ID: 3055

UniProt: P08631

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling