Aurora A antibody

Catalog No. ABIN750053

The Rabbit Polyclonal anti-Aurora A antibody has been validated for WB, IHC (p) and IF (p). It is suitable to detect Aurora A in samples from Human, Mouse, Rat, Cow and Pig.

Quick Overview for Aurora A antibody (ABIN750053)

Target: Aurora A (AURKA) (Aurora Kinase A (AURKA))

Reactivity: Human, Mouse, Rat, Cow, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Aurora A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Aurora A Antibody

Cross-Reactivity: Cow, Human, Mouse, Pig, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Auroa A

Isotype: IgG

Application Details

Application Notes: WB(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for Aurora A

Target: Aurora A (AURKA) (Aurora Kinase A (AURKA))

Alternative Name: Aurora A

Background:

Synonyms: Aurora A Thr288, p-Aurora AT288, AIK, ARK-1, ARK1, AURA, AURKA, Aurora 2, Aurora A, Aurora A, Aurora Family Kinase 1, aurora kinase A, Aurora Related Kinase 1, Aurora-related kinase 1, Aurora/IPL1 Like Kinase, Aurora/IPL1 Related Kinase 1, Aurora/IPL1-related kinase 1, AURORA2, AYK1, BRAK, Breast Tumor Amplied Kinase, Breast tumor-amplied kinase, BTAK, hARK1, IAK, IPL1 Aurora Related Kinase 1, IPL1 Related Kinase, MGC34538, OTTHUMP00000031340, OTTHUMP00000031341, OTTHUMP00000031342, OTTHUMP00000031343, OTTHUMP00000031344, OTTHUMP00000031345, OTTHUMP00000166071, OTTHUMP00000166072, PPP1R47, Protein phosphatase 1, regulatory subunit 47, Serine/threonine kinase 15, Serine/threonine kinase 6, Serine/threonine kinase, Serine/threonine kinase, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase aurora-A, STK15, STK6, STK6_HUMAN, STK7.

Background: Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment.

Molecular Weight: 48kDa

Gene ID: 6790

Pathways: Cell Division Cycle, Asymmetric Protein Localization