Hexokinase 1 antibody (AA 17-323) (Fluoro488)

Catalog No. ABIN7997411

The Fluoro488-conjugated Mouse Monoclonal anti-Hexokinase 1 antibody (Clone 2I4) (ABIN7997411) specifically detects Hexokinase 1 in FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Hexokinase 1 antibody (AA 17-323) (Fluoro488) (ABIN7997411)

Target: Hexokinase 1 (HK1)

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Hexokinase 1 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Clone: 2I4

Product Details anti-Hexokinase 1 Antibody (Fluoro488)

Binding Specificity: AA 17-323

Purpose: Anti-Hexokinase 1/HK1 Antibody (monoclonal, 2I4) Fluoro488 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Hexokinase 1/HK1 recombinant protein (Position: D17-R323).

Isotype: IgG2b

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Hexokinase 1

Target: Hexokinase 1 (HK1)

Alternative Name: HK1

Background:

Background: Hexokinase-1 (HK1) is an enzyme that in humans is encoded by the HK1 gene on chromosome 10. It is mapped to 10q22.1. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in several transcript variants which encode different isoforms, some of which are tissue-specific.

Gene Full Name: hexokinase 1

Gene ID: 3098

UniProt: P19367

Pathways: Carbohydrate Homeostasis, Warburg Effect