HCN1 antibody (AA 618-890) (APC)

Catalog No. ABIN7998902

The APC-conjugated Rabbit Polyclonal anti-HCN1 antibody (ABIN7998902) specifically detects HCN1 in WB. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for HCN1 antibody (AA 618-890) (APC) (ABIN7998902)

Target: HCN1 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HCN1 antibody is conjugated to APC

Application: Western Blotting (WB)

Product Details anti-HCN1 Antibody (APC)

Binding Specificity: AA 618-890

Purpose: Anti-HCN1 Antibody APC Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human HCN1 shares 82% amino acid (aa) sequence identity with both mouse,rat HCN1.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human HCN1 recombinant protein (Position: E618-L890). Human HCN1 shares 82% amino acid (aa) sequence identity with both mouse and rat HCN1.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat

Comment:

Applications are recommended based on the unconjugated antibody.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for HCN1

Target: HCN1 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1))

Alternative Name: HCN1

Background:

Background: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, also known as HAC-2 or BCNG-1, is a protein that in humans is encoded by the HCN1 gene. It is mapped to 5p12. The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. It may mediates responses to sour stimuli.

Gene Full Name: hyperpolarization activated cyclic nucleotide gated potassium channel 1

Sequence Similarities: Belongs to the potassium channel HCN family.

Gene ID: 348980

UniProt: O60741

Pathways: Asymmetric Protein Localization