ITM2C antibody (AA 33-226) (FITC)

Catalog No. ABIN8000247

The Rabbit Polyclonal anti-ITM2C antibody is suitable to detect ITM2C in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for ITM2C antibody (AA 33-226) (FITC) (ABIN8000247)

Target: ITM2C (Integral Membrane Protein 2C (ITM2C))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITM2C antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Product Details anti-ITM2C Antibody (FITC)

Binding Specificity: AA 33-226

Purpose: Anti-ITM2C Antibody FITC Conjugated

Predicted Reactivity: Human ITM2C shares 94.8% amino acid (aa) sequence identity with mouse,rat ITM2C.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human ITM2C recombinant protein (Position: E33-D226). Human ITM2C shares 94.8% amino acid (aa) sequence identity with mouse and rat ITM2C.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for ITM2C

Target: ITM2C (Integral Membrane Protein 2C (ITM2C))

Alternative Name: ITM2C

Background:

Background: Integral membrane protein 2C is a protein that in humans is encoded by the ITM2C gene. The Integral membrane protein 2C (ITM2C) is a type II integral transmembrane protein belonging to a family composed of at least two other members, ITM2A and ITM2B. ITM2C, often called transmembrane protein BRI3, is highly expressed in brain tissue. Yeast two-hybrid screen system revealed that BRI3 could interact with beta-secretase beta-amyloid protein converting enzyme (BACE)1 and the microtubule-destabilizing protein SCG10 (STMN2). It may play a role in TNF-induced cell death and neuronal differentiation. BRI3 was found to inhibit the various processing of amyloid precursor protein (APP) by blocking the access of alpha- and beta-secretases to APP, competitive inhibition of APP processing by BRI3 may provide a new approach to Alzheimer disease (AD) therapy and prevention.

Gene Full Name: integral membrane protein 2C

Gene ID: 81618

UniProt: Q9NQX7