IL-18 antibody (AA 36-192) (Cy3)

Catalog No. ABIN8002080

The Rabbit Polyclonal anti-IL-18 antibody is suitable to detect IL-18 in samples from Mouse. It has been validated for FACS.

Quick Overview for IL-18 antibody (AA 36-192) (Cy3) (ABIN8002080)

Target: IL-18 (IL18) (Interleukin 18 (IL18))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-18 antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-IL-18 Antibody (Cy3)

Binding Specificity: AA 36-192

Purpose: Anti-IL18 Antibody Cy3 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Mouse IL-18 shares 66%,91% amino acid (aa) sequence identity with human,rat IL-18,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse IL-18 recombinant protein (Position: N36-S192). Mouse IL-18 shares 66% and 91% amino acid (aa) sequence identity with human and rat IL-18, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for IL-18

Target: IL-18 (IL18) (Interleukin 18 (IL18))

Alternative Name: IL18

Background:

Background: < a href=https://www.bosterbio.com/anti-il-18-antibody-pa1342-boster.html style=color:#EA8D28>Interleukin-18, also known as IL18, is a protein which in humans is encoded by the IL18 gene. IL-18 is a cytokine produced by macrophages and other cells that belongs to the IL-1 superfamily. It is mapped to 11q22.2-q22.3. IL-18 works by binding to the interleukin-18 receptor, and together with IL-12, it induces cell-mediated immunity following infection with microbial products like lipopolysaccharide (LPS). After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-γ (IFN-γ) or type II interferon that plays an important role in activating the macrophages or other cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production in B cells.

Gene Full Name: interleukin 18

Sequence Similarities: Belongs to the IL-15/IL-21 family.

Gene ID: 16173

UniProt: P70380

Pathways: Cellular Response to Molecule of Bacterial Origin, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome