IL-18 antibody (AA 37-194) (Fluoro488)

Catalog No. ABIN8002147

The Fluoro488-conjugated Rabbit Polyclonal anti-IL-18 antibody (ABIN8002147) specifically detects IL-18 in FACS. The antibody is reactive with Mouse and Rat samples.

Quick Overview for IL-18 antibody (AA 37-194) (Fluoro488) (ABIN8002147)

Target: IL-18 (IL18) (Interleukin 18 (IL18))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-18 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-IL-18 Antibody (Fluoro488)

Binding Specificity: AA 37-194

Purpose: Anti-IL18 Antibody Fluoro488 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Rat IL-18 shares 64%,91% amino acid (aa) sequences identity with human,mouse IL-18,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived rat IL-18 recombinant protein (Position: H37-S194). Rat IL-18 shares 64% and 91% amino acid (aa) sequences identity with human and mouse IL-18, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for IL-18

Target: IL-18 (IL18) (Interleukin 18 (IL18))

Alternative Name: IL18

Background:

Background: Interleukin (IL)-18, also called Interferon-gamma-inducing factor (IGIF), augments natural killer (NK) activity in spleen cells. The gene encodes a precursor protein of 192 amino acids and a mature protein of 157 amino acids. IL18 is a recently discovered cytokine that modulates both T helper type 1 (Th1) and Th2 responses. IL18 is a potent proinflammatory cytokine with potential atherogenic properties. It is highly expressed in the atherosclerotic plaques compared with control normal arteries and is localized mainly in plaque macrophages.

Gene Full Name: interleukin 18

Sequence Similarities: Belongs to the CNTF family.

Gene ID: 29197

UniProt: P97636

Pathways: Cellular Response to Molecule of Bacterial Origin, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome