IL21 Receptor antibody (Middle Region) (Fluoro647)

Catalog No. ABIN8002330

The Fluoro647-conjugated Rabbit Polyclonal anti-IL21 Receptor antibody (ABIN8002330) specifically detects IL21 Receptor in FACS. The antibody is reactive with Human samples.

Quick Overview for IL21 Receptor antibody (Middle Region) (Fluoro647) (ABIN8002330)

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL21 Receptor antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-IL21 Receptor Antibody (Fluoro647)

Binding Specificity: Middle Region

Purpose: Anti-IL21R Antibody Fluoro647 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human IL21R shares 78.6% amino acid (aa) sequence identity with mouse IL21R.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human IL21R. Human IL21R shares 78.6% amino acid (aa) sequence identity with mouse IL21R.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for IL21 Receptor

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Alternative Name: IL21R

Background:

Background: The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.

Gene Full Name: interleukin 21 receptor

Gene ID: 50615

UniProt: Q9HBE5

Pathways: JAK-STAT Signaling