IL3RA antibody (Middle Region) (Biotin)

Catalog No. ABIN8002530

The Rabbit Polyclonal anti-IL3RA antibody is suitable to detect IL3RA in samples from Human. It has been validated for WB, IHC and ELISA.

Quick Overview for IL3RA antibody (Middle Region) (Biotin) (ABIN8002530)

Target: IL3RA (Interleukin 3 Receptor, alpha (IL3RA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL3RA antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-IL3RA Antibody (Biotin)

Binding Specificity: Middle Region

Purpose: Anti-IL3RA Antibody Biotin Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human IL3RA.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for IL3RA

Target: IL3RA (Interleukin 3 Receptor, alpha (IL3RA))

Alternative Name: IL3RA

Background:

Background: IL3RA (INTERLEUKIN 3 RECEPTOR, ALPHA), also called CD123 (Cluster of Differentiation 123), is a human gene. The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor which is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The IL3RA is mapped on Xp22.33. The genomic structures of IL3RA and CSF2RA are very similar and share an additional exon encoding part of the C-terminal domain not found in other members of this gene family. As in human hematopoietic cells, IL3 and GMCSF competed for binding in fibroblasts expressing the cDNAs for IL3RA, CSF2RA, and the common beta subunit, indicating that different alpha subunits compete for a common beta subunit.

Gene Full Name: interleukin 3 receptor subunit alpha

Sequence Similarities: Belongs to the type I cytokine receptor family. Type 5 subfamily.

Gene ID: 3563

UniProt: P26951

Pathways: JAK-STAT Signaling