IL7R antibody (AA 33-433) (Fluoro550)

Catalog No. ABIN8002863

The Rabbit Polyclonal anti-IL7R antibody is suitable to detect IL7R in samples from Human. It has been validated for FACS.

Quick Overview for IL7R antibody (AA 33-433) (Fluoro550) (ABIN8002863)

Target: IL7R (Interleukin 7 Receptor (IL7R))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL7R antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-IL7R Antibody (Fluoro550)

Binding Specificity: AA 33-433

Purpose: Anti-CD127/IL7R Antibody Fluoro550 Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human IL7R shares 63.1% amino acid (aa) sequence identity with mouse IL7R.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human CD127/IL7R recombinant protein (Position: A33-Q433). Human IL7R shares 63.1% amino acid (aa) sequence identity with mouse IL7R.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for IL7R

Target: IL7R (Interleukin 7 Receptor (IL7R))

Alternative Name: IL7R

Background:

Background: The interleukin-7 receptor, also known as IL7R alpha, is a protein found on the surface of cells. It is mapped to 5p13. Interleukin-7 receptor has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known as V(D)J recombination. This protein is also found to control the accessibility of a region of the genome that contains the T-cell receptor gamma gene, by STAT5 and histone acetylation. Knockout studies in mice suggest that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. Functional defects in this protein may be associated with the pathogenesis of severe combined immunodeficiency (SCID).

Gene Full Name: interleukin 7 receptor

Gene ID: 3575

UniProt: P16871

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size