ICMT antibody (AA 13-284) (Fluoro488)

Catalog No. ABIN8003511

The Rabbit Polyclonal anti-ICMT antibody is suitable to detect ICMT in samples from Human and Rat. It has been validated for FACS.

Quick Overview for ICMT antibody (AA 13-284) (Fluoro488) (ABIN8003511)

Target: ICMT (Isoprenylcysteine Carboxyl Methyltransferase (ICMT))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ICMT antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-ICMT Antibody (Fluoro488)

Binding Specificity: AA 13-284

Purpose: Anti-ICMT Antibody Fluoro488 Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human ICMT shares 96.3%,95.2% amino acid (aa) sequence identity with mouse,rat ICMT,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human ICMT recombinant protein (Position: E13-L284). Human ICMT shares 96.3% and 95.2% amino acid (aa) sequence identity with mouse and rat ICMT, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for ICMT

Target: ICMT (Isoprenylcysteine Carboxyl Methyltransferase (ICMT))

Alternative Name: ICMT

Background:

Background: Protein-S-isoprenylcysteine O-methyltransferase is an enzyme that in humans is encoded by the ICMT gene. This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.

Gene Full Name: isoprenylcysteine carboxyl methyltransferase

Gene ID: 23463

UniProt: O60725