KIAA1524 antibody (C-Term) (PE)

Catalog No. ABIN8004353

This Rabbit Polyclonal antibody specifically detects KIAA1524 in FACS. It exhibits reactivity toward Human and Mouse.

Quick Overview for KIAA1524 antibody (C-Term) (PE) (ABIN8004353)

Target: KIAA1524

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIAA1524 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-KIAA1524 Antibody (PE)

Binding Specificity: C-Term

Purpose: Anti-p90 Autoantigen/KIAA1524 CIP2A Antibody PE Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: different from the related mouse sequence by three amino acids.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human KIAA1524, different from the related mouse sequence by three amino acids.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for KIAA1524

Target: KIAA1524

Alternative Name: CIP2A

Background:

Background: Protein CIP2A, also known as cancerous inhibitor of PP2A  (CIP2A), is a protein that in humans is encoded by the KIAA1524 gene. CIP2A is required for the malignant cellular growth and for in vivo tumor formation. In accordance with the oncogenic role of CIP2A, overexpression of CIP2A promotes Ras-elicited cell growth and transforms immortalized human cells (HEK-TERVs). More recently CIP2A has been shown to regulate phosphorylation and activity of many other oncoproteins and to drive malignant cell growth and tumorigenesis in various human cancer types. Importantly, CIP2A deficient mice are viable, suggesting that targeting of oncogenic function of CIP2A would not result in serious side-effects.

Gene Full Name: cellular inhibitor of PP2A

Gene ID: 57650

UniProt: Q8TCG1