KIF2C antibody (AA 531-725) (HRP)

Catalog No. ABIN8004483

The Rabbit Polyclonal anti-KIF2C antibody is suitable to detect KIF2C in samples from Human, Mouse and Rat. It has been validated for WB, IHC and ELISA.

Quick Overview for KIF2C antibody (AA 531-725) (HRP) (ABIN8004483)

Target: KIF2C (Kinesin Family Member 2C (KIF2C))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIF2C antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-KIF2C Antibody (HRP)

Binding Specificity: AA 531-725

Purpose: Anti-MCAK/KIF2C Antibody HRP Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human MCAK shares 87% amino acid (aa) sequence identity with both mouse,rat MCAK.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MCAK recombinant protein (Position: G531-Q725). Human MCAK shares 87% amino acid (aa) sequence identity with both mouse and rat MCAK.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for KIF2C

Target: KIF2C (Kinesin Family Member 2C (KIF2C))

Alternative Name: KIF2C

Background:

Background: Kinesin-like protein KIF2C is a protein that in humans is encoded by the KIF2C gene. It is mapped to 1p34.1. The protein encoded by this gene is a member of kinesin-like protein family. Most proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein acts to regulate microtubule dynamics in cells and is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation. KIF2C uses microtubule depolymerizing activity to correct improper microtubule attachments at kinetochores.

Gene Full Name: kinesin family member 2C

Sequence Similarities: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.

Gene ID: 11004

UniProt: Q99661

Pathways: Microtubule Dynamics