Lamin B1 antibody (C-Term) (Fluoro550)

Catalog No. ABIN8005020

The Rabbit Polyclonal anti-Lamin B1 antibody is suitable to detect Lamin B1 in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for Lamin B1 antibody (C-Term) (Fluoro550) (ABIN8005020)

Target: Lamin B1 (LMNB1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Lamin B1 antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-Lamin B1 Antibody (Fluoro550)

Binding Specificity: C-Term

Purpose: Anti-Lamin B1/LMNB1 Antibody Fluoro550 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: different from the related rat sequence by one amino acid,and from the related mouse sequence by three amino acids.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Lamin B1, different from the related rat sequence by one amino acid, and from the related mouse sequence by three amino acids.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Lamin B1

Target: Lamin B1 (LMNB1)

Alternative Name: LMNB1

Background:

Background: Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are though to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1.

Gene Full Name: lamin B1

Sequence Similarities: Belongs to the intermediate filament family.

Gene ID: 4001

UniProt: P20700

Pathways: Apoptosis, Caspase Cascade in Apoptosis