LEPREL1 antibody (AA 106-494) (Biotin)

Catalog No. ABIN8005346

This Rabbit Polyclonal antibody specifically detects LEPREL1 in WB, ELISA and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for LEPREL1 antibody (AA 106-494) (Biotin) (ABIN8005346)

Target: LEPREL1 (Leprecan Like Protein 1 (LEPREL1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LEPREL1 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-LEPREL1 Antibody (Biotin)

Binding Specificity: AA 106-494

Purpose: Anti-P3H2 Antibody Biotin Conjugated

Predicted Reactivity: Human P3H2 shares 88.9%,89.5% amino acid (aa) sequence identity with mouse,rat P3H2,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human P3H2 recombinant protein (Position: E106-R494). Human P3H2 shares 88.9% and 89.5% amino acid (aa) sequence identity with mouse and rat P3H2, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for LEPREL1

Target: LEPREL1 (Leprecan Like Protein 1 (LEPREL1))

Alternative Name: P3H2

Background:

Background: This gene encodes a member of the prolyl 3-hydroxylase subfamily of 2-oxo-glutarate-dependent dioxygenases. These enzymes play a critical role in collagen chain assembly, stability and cross-linking by catalyzing post-translational 3-hydroxylation of proline residues. Mutations in this gene are associated with nonsyndromic severe myopia with cataract and vitreoretinal degeneration, and downregulation of this gene may play a role in breast cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene Full Name: prolyl 3-hydroxylase 2

Gene ID: 55214

UniProt: Q8IVL5