LRRC1 antibody (AA 120-497) (Cy3)

Catalog No. ABIN8005457

This Rabbit Polyclonal antibody specifically detects LRRC1 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for LRRC1 antibody (AA 120-497) (Cy3) (ABIN8005457)

Target: LRRC1 (Leucine Rich Repeat Containing 1 (LRRC1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRRC1 antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-LRRC1 Antibody (Cy3)

Binding Specificity: AA 120-497

Purpose: Anti-LRRC1 Antibody Cy3 Conjugated

Predicted Reactivity: Human LRRC1 shares 91.8% amino acid (aa) sequence identity with mouse LRRC1.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human LRRC1 recombinant protein (Position: L120-R497). Human LRRC1 shares 91.8% amino acid (aa) sequence identity with mouse LRRC1.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for LRRC1

Target: LRRC1 (Leucine Rich Repeat Containing 1 (LRRC1))

Alternative Name: LRRC1

Background:

Background: Lano is a member of the LAP (leucine-rich repeats and PDZ) family of proteins that also includes Densin-180, Erbin, and hScribble. The LAP proteins generally contain multiple leucine-rich repeat (LRR) domains which serve to target them to the basolateral membrane of epithelial cells. Lano is unique in that it alone does not possess one or more PDZ (PSD95/DLG/ZO-1) domains as do the other members of the LAP family. However, it can bind to the PDZ domain of Erbin in addition to those of membrane-associated and guanylate kinase (MAGUK) proteins which regulate adhesion and plasticity at cell junctions. It has been suggested that it is through these interaction that these LAP proteins participate in the maintenance of proper embryonic development and integrity of epithelial tissues.

Gene Full Name: leucine rich repeat containing 1

Gene ID: 55227

UniProt: Q9BTT6