LARS antibody (HRP)

Catalog No. ABIN8005827

The Rabbit Polyclonal anti-LARS antibody is suitable to detect LARS in samples from Human, Mouse and Rat. It has been validated for WB, IHC and ELISA.

Quick Overview for LARS antibody (HRP) (ABIN8005827)

Target: LARS (Leucyl-tRNA Synthetase (LARS))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LARS antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-LARS Antibody (HRP)

Purpose: Anti-Leucyl tRNA synthetase /LARS Antibody HRP Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human Leucyl tRNA synthetase/LARS recombinant protein (Q628-Q855).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for LARS

Target: LARS (Leucyl-tRNA Synthetase (LARS))

Alternative Name: LARS

Background:

Background: Leucyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the LARS gene. This gene is mapped to 5q32. It encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA (Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed.

Gene Full Name: leucyl-tRNA synthetase 1

Gene ID: 51520

UniProt: Q9P2J5

Pathways: EGFR Signaling Pathway