LIMS1 antibody (AA 11-172) (APC)

Catalog No. ABIN8006004

The Rabbit Polyclonal anti-LIMS1 antibody is suitable to detect LIMS1 in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for LIMS1 antibody (AA 11-172) (APC) (ABIN8006004)

Target: LIMS1 (LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LIMS1 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-LIMS1 Antibody (APC)

Binding Specificity: AA 11-172

Purpose: Anti-LIMS1 Antibody APC Conjugated

Predicted Reactivity: Human LIMS1 shares 100% amino acid (aa) sequence identity with mouse LIMS1.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human LIMS1 recombinant protein (Position: E11-A172). Human LIMS1 shares 100% amino acid (aa) sequence identity with mouse LIMS1.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for LIMS1

Target: LIMS1 (LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1))

Alternative Name: LIMS1

Background:

Background: LIM and senescent cell antigen-like-containing domain protein 1 is a protein that in humans is encoded by the LIMS1 gene. The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: LIM zinc finger domain containing 1

Gene ID: 3987

UniProt: P48059