LDLR antibody (AA 35-843) (Fluoro647)

Catalog No. ABIN8006545

The Fluoro647-conjugated Rabbit Polyclonal anti-LDLR antibody (ABIN8006545) specifically detects LDLR in FACS. The antibody is reactive with Human and Rat samples.

Quick Overview for LDLR antibody (AA 35-843) (Fluoro647) (ABIN8006545)

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LDLR antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-LDLR Antibody (Fluoro647)

Binding Specificity: AA 35-843

Purpose: Anti-LDL Receptor/LDLR Antibody Fluoro647 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human LDL Receptor/LDLR recombinant protein (Position: Q35-D843).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for LDLR

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Alternative Name: LDLR

Background:

Background: In humans, the LDL receptor protein is encoded by the LDLR gene on chromosome 19. It is mapped to 19p13.2. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

Gene Full Name: low density lipoprotein receptor

Gene ID: 3949

UniProt: P01130

Pathways: Hepatitis C, Lipid Metabolism