MADD antibody (AA 5-329) (APC)

Catalog No. ABIN8007809

This Rabbit Polyclonal antibody specifically detects MADD in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for MADD antibody (AA 5-329) (APC) (ABIN8007809)

Target: MADD (MAP-Kinase Activating Death Domain (MADD))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MADD antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-MADD Antibody (APC)

Binding Specificity: AA 5-329

Purpose: Anti-MADD Antibody APC Conjugated

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MADD recombinant protein (Position: K5-Y329).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for MADD

Target: MADD (MAP-Kinase Activating Death Domain (MADD))

Alternative Name: MADD

Background:

Background: MAP kinase-activating death domain protein is an enzyme that in humans is encoded by the MADD gene. Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene.

Gene Full Name: MAP kinase activating death domain

Gene ID: 8567

UniProt: Q8WXG6

Pathways: Caspase Cascade in Apoptosis