MESDC2 antibody (AA 80-205) (PE)

Catalog No. ABIN8009196

The Rabbit Polyclonal anti-MESDC2 antibody is suitable to detect MESDC2 in samples from Human. It has been validated for FACS.

Quick Overview for MESDC2 antibody (AA 80-205) (PE) (ABIN8009196)

Target: MESDC2 (Mesoderm Development Candidate 2 (MESDC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MESDC2 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-MESDC2 Antibody (PE)

Binding Specificity: AA 80-205

Purpose: Anti-MESDC2/MESD Antibody PE Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MESDC2/MESD recombinant protein (Position: D80-Q205).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for MESDC2

Target: MESDC2 (Mesoderm Development Candidate 2 (MESDC2))

Alternative Name: MESD

Background:

Background: Mesoderm development candidate genes 1 (MESDC1) and 2 (MESDC2) were identified from the mesoderm development (MESD) deletion interval located on mouse chromosome 7. MESD acts as a chaperone for low-density lipoprotein receptor (LDLR) proteins in the ER, and particularly associates with Wnt signaling pathway coreceptors LRP5 and LPR6. MESD is required for proper LRP5/6 folding and maturation to the cell surface, which plays a major role in Wnt signaling. The interaction between MESD and LRP5 is disrupted by a G171V mutation in LRP5 that is found in individuals with a familial phenotype characterized by high bone mass.

Gene Full Name: mesoderm development LRP chaperone

Gene ID: 23184

UniProt: Q14696