MTDH antibody (AA 101-270) (Cy3)

Catalog No. ABIN8009299

The Cy3-conjugated Rabbit Polyclonal anti-MTDH antibody (ABIN8009299) specifically detects MTDH in FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for MTDH antibody (AA 101-270) (Cy3) (ABIN8009299)

Target: MTDH (Metadherin (MTDH))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MTDH antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-MTDH Antibody (Cy3)

Binding Specificity: AA 101-270

Purpose: Anti-LYRIC/MTDH Antibody Cy3 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human LYRIC shares 94% amino acid (aa) sequence identity with both mouse,rat LYRIC.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human LYRIC recombinant protein (Position: D101-Q270). Human LYRIC shares 94% amino acid (aa) sequence identity with both mouse and rat LYRIC.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for MTDH

Target: MTDH (Metadherin (MTDH))

Alternative Name: MTDH

Background:

Background: MTDH (Metadherin), also known as protein LYRIC or astrocyte elevated gene-1 protein (AEG-1) is a protein that in humans is encoded by the MTDH gene. AEG-1 is involved in HIF-1alpha mediated angiogenesis. AEG-1 also interacts with SND1 and involved in RNA-induced silencing complex (RISC) and plays very important role in RISC and miRNA functions. AEG-1 induces an oncogene called Late SV40 factor (LSF/TFCP2) which is involved in thymidylate synthase (TS) induction and DNA biosynthesis synthesis. Late SV40 factor (LSF/TFCP2) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9). AEG-1 acts as an oncogene in melanoma, malignant glioma, breast cancer and hepatocellular carcinoma. It is highly expressed in these cancers and helps in progression and development of these cancers. It is induced by c-Myc oncogene and plays very important role in anchorage independent growth of cancer cells.

Gene Full Name: metadherin

Sequence Similarities: Belongs to the chaperonin (HSP60) family.

Gene ID: 92140

UniProt: Q86UE4

Pathways: Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization