MECP2 antibody (AA 36-437) (HRP)

Catalog No. ABIN8009557

The HRP-conjugated Rabbit Polyclonal anti-MECP2 antibody (ABIN8009557) specifically detects MECP2 in WB, IHC and ELISA. The antibody is reactive with Human, Mouse, Rat and Monkey samples.

Quick Overview for MECP2 antibody (AA 36-437) (HRP) (ABIN8009557)

Target: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MECP2 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-MECP2 Antibody (HRP)

Binding Specificity: AA 36-437

Purpose: Anti-MECP2 Antibody HRP Conjugated

Predicted Reactivity: Human MECP2 shares 95.8%,96% amino acid (aa) sequence identity with mouse,rat MECP2,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MECP2 recombinant protein (Position: K36-Q437). Human MECP2 shares 95.8% and 96% amino acid (aa) sequence identity with mouse and rat MECP2, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for MECP2

Target: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Alternative Name: MECP2

Background:

Background: MECP2?(methyl CpG binding protein 2) is a?gene?that encodes the?protein?MECP2. It is mapped to Xq28. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Full Name: methyl-CpG binding protein 2

Gene ID: 4204

UniProt: P51608

Pathways: Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane