MYLK antibody (AA 1441-1709) (Cy3)

Catalog No. ABIN8012755

The Cy3-conjugated Rabbit Polyclonal anti-MYLK antibody (ABIN8012755) specifically detects MYLK in FACS. The antibody is reactive with Human and Rat samples.

Quick Overview for MYLK antibody (AA 1441-1709) (Cy3) (ABIN8012755)

Target: MYLK (Myosin Light Chain Kinase (MYLK))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYLK antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-MYLK Antibody (Cy3)

Binding Specificity: AA 1441-1709

Purpose: Anti-Myosin light chain kinase/MYLK Antibody Cy3 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human MYLK recombinant protein (Position: D1441-D1709).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for MYLK

Target: MYLK (Myosin Light Chain Kinase (MYLK))

Alternative Name: MYLK

Background:

Background: Myosin light chain kinase, smooth muscle also known as kinase-related protein (KRP) or telokin is an enzyme that in humans is encoded by the MYLK gene. This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin.

Gene Full Name: myosin light chain kinase

Gene ID: 4638

UniProt: Q15746