NAE1 antibody (AA 181-534) (Fluoro647)

Catalog No. ABIN8014172

This Rabbit Polyclonal antibody specifically detects NAE1 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for NAE1 antibody (AA 181-534) (Fluoro647) (ABIN8014172)

Target: NAE1 (NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NAE1 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-NAE1 Antibody (Fluoro647)

Binding Specificity: AA 181-534

Purpose: Anti-APPBP1/NAE1 Antibody Fluoro647 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human APPBP1 shares 98% amino acid (aa) sequence identity with mouse APPBP1.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human APPBP1 recombinant protein (Position: E181-L534). Human APPBP1 shares 98% amino acid (aa) sequence identity with mouse APPBP1.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for NAE1

Target: NAE1 (NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))

Alternative Name: NAE1

Background:

Background: NAE1 is also known as APPBP1. The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: NEDD8 activating enzyme E1 subunit 1

Gene ID: 8883

UniProt: Q13564