FcRn antibody (AA 54-291) (Biotin)

Catalog No. ABIN8014229

This Rabbit Polyclonal antibody specifically detects FcRn in WB, ELISA and IHC. It exhibits reactivity toward Mouse.

Quick Overview for FcRn antibody (AA 54-291) (Biotin) (ABIN8014229)

Target: FcRn (neonatal Fc Receptor (FcRn))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FcRn antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-FcRn Antibody (Biotin)

Binding Specificity: AA 54-291

Purpose: Anti-FCGRT Antibody Biotin Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: coli-derived mouse FCGRT recombinant protein (Position: Q54-D291). Mouse FCGRT shares 70.2%,92.4% amino acid (aa) sequence identity with human,rat FCGRT,respectively.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived mouse FCGRT recombinant protein (Position: Q54-D291). Mouse FCGRT shares 70.2% and 92.4% amino acid (aa) sequence identity with human and rat FCGRT, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for FcRn

Target: FcRn (neonatal Fc Receptor (FcRn))

Alternative Name: Fcgrt

Background:

Background: IgG receptor FcRn large subunit p51?is a?protein?that in humans is encoded by the?FCGRT?gene. This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation.?In addition, it is postulated that long-range cis inactivation of the?FCGRT?gene is responsible for hypercatabolism of IgG in myotonic dystrophy. The?FCGRT?gene is closely situated to the DMPK gene, which is mutant in DM.?

Gene Full Name: Fc fragment of IgG receptor and transporter

Gene ID: 14132

UniProt: Q61559

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process