FcRn antibody (AA 54-291) (Cy3)

Catalog No. ABIN8014230

The Rabbit Polyclonal anti-FcRn antibody is suitable to detect FcRn in samples from Mouse. It has been validated for FACS.

Quick Overview for FcRn antibody (AA 54-291) (Cy3) (ABIN8014230)

Target: FcRn (neonatal Fc Receptor (FcRn))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FcRn antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-FcRn Antibody (Cy3)

Binding Specificity: AA 54-291

Purpose: Anti-FCGRT Antibody Cy3 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: coli-derived mouse FCGRT recombinant protein (Position: Q54-D291). Mouse FCGRT shares 70.2%,92.4% amino acid (aa) sequence identity with human,rat FCGRT,respectively.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived mouse FCGRT recombinant protein (Position: Q54-D291). Mouse FCGRT shares 70.2% and 92.4% amino acid (aa) sequence identity with human and rat FCGRT, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for FcRn

Target: FcRn (neonatal Fc Receptor (FcRn))

Alternative Name: Fcgrt

Background:

Background: IgG receptor FcRn large subunit p51?is a?protein?that in humans is encoded by the?FCGRT?gene. This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation.?In addition, it is postulated that long-range cis inactivation of the?FCGRT?gene is responsible for hypercatabolism of IgG in myotonic dystrophy. The?FCGRT?gene is closely situated to the DMPK gene, which is mutant in DM.?

Gene Full Name: Fc fragment of IgG receptor and transporter

Gene ID: 14132

UniProt: Q61559

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process