Netrin 3 antibody (AA 51-473) (Fluoro488)

Catalog No. ABIN8014385

This Rabbit Polyclonal antibody specifically detects Netrin 3 in FACS. It exhibits reactivity toward Human and Rat.

Quick Overview for Netrin 3 antibody (AA 51-473) (Fluoro488) (ABIN8014385)

Target: Netrin 3 (Ntn3)

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Netrin 3 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-Netrin 3 Antibody (Fluoro488)

Binding Specificity: AA 51-473

Purpose: Anti-NTN3 Antibody Fluoro488 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human NTN3 recombinant protein (Position: R51-R473).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Netrin 3

Target: Netrin 3 (Ntn3)

Alternative Name: NTN3

Background:

Background: Netrins are a family of highly conserved proteins responsible for axon guidance and cell movement throughout neural development. Netrins can be divided into secreted netrins (netrin 1,3,4 and 5) and membrane-tethered glycophosphatidylinositol (GPI)-linked netrins (netrin G1 and G2).Secreted netrins carry their function via interaction with several receptors that include the deleted in colorectal (DCC) family, and the uncoordinated-5 (UNC5-A through UNC5-D) family.Netrin-3 was discovered in 1997 using sequence homology searching of netrin-2. Similarly to other netrins, Netrin-3 plays an important role in the development of the nervous system. Netrin-3 structure consist of a laminin-like domain located on the N-terminal, three epidermal growth factors like repeats (EGF), and a C-terminal netrin-like domain (NTR). Mutations in NTN3, the gene encoding netrin-3 was found to be associated with the development of several carcinomas.

Gene Full Name: netrin 3

Gene ID: 4917

UniProt: O00634

Pathways: Regulation of Muscle Cell Differentiation