Neuregulin 2 antibody (Middle Region)

Catalog No. ABIN8014558

The Rabbit Polyclonal anti-Neuregulin 2 antibody (ABIN8014558) specifically detects Neuregulin 2 in WB. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for Neuregulin 2 antibody (Middle Region) (ABIN8014558)

Target: Neuregulin 2 (NRG2)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neuregulin 2 antibody is un-conjugated

Application: Western Blotting (WB)

Grade: Carrier-free

Product Details anti-Neuregulin 2 Antibody

Binding Specificity: Middle Region

Purpose: Anti-NRG2 Antibody

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: identical to the related rat sequence,and different from the related mouse sequence by one amino acid.

Characteristics: Anti-NRG2 Antibody. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human NRG2, identical to the related rat sequence, and different from the related mouse sequence by one amino acid.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Sodium azide, Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Neuregulin 2

Target: Neuregulin 2 (NRG2)

Alternative Name: NRG2

Background:

Background: Neuregulin 2, also known as NRG2, DON1 or NTAK, is a protein that in humans is encoded by the NRG2 gene. Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. The NRG2 gene is mapped to 5q31.2. Through interaction with the ErbB family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The human NRG2 gene contains 12 exons and the mouse Nrg2 gene contains 12 exons and spans about 180 kb. The NRG2 genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. In particular, the neuregulin-ERBB signaling pathways play crucial roles in regulating the proliferation and differentiation of Schwann cells, the myelin-forming cells in the peripheral nervous system.

Gene Full Name: neuregulin 2

Sequence Similarities: Belongs to the neuregulin family.

Molecular Weight: 91 kDa

Gene ID: 9542

UniProt: O14511

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway