NFS1 antibody (AA 107-356) (Fluoro550)

Catalog No. ABIN8015321

This Rabbit Polyclonal antibody specifically detects NFS1 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for NFS1 antibody (AA 107-356) (Fluoro550) (ABIN8015321)

Target: NFS1 (NFS1, Cysteine Desulfurase (NFS1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NFS1 antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-NFS1 Antibody (Fluoro550)

Binding Specificity: AA 107-356

Purpose: Anti-NFS1 Antibody Fluoro550 Conjugated

Predicted Reactivity: Human NFS1 shares 96.4%,96% amino acid (aa) sequence identity with mouse,rat NFS1,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human NFS1 recombinant protein (Position: R107-L356). Human NFS1 shares 96.4% and 96% amino acid (aa) sequence identity with mouse and rat NFS1, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for NFS1

Target: NFS1 (NFS1, Cysteine Desulfurase (NFS1))

Alternative Name: NFS1

Background:

Background: Cysteine desulfurase, mitochondrial is an enzyme that in humans is encoded by the NFS1 gene. Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH . The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described.

Gene Full Name: NFS1 cysteine desulfurase

Gene ID: 9054

UniProt: Q9Y697

Pathways: Transition Metal Ion Homeostasis