NHEJ1 antibody (AA 1-273) (Fluoro550)

Catalog No. ABIN8016092

This Rabbit Polyclonal antibody specifically detects NHEJ1 in FACS. It exhibits reactivity toward Human and Mouse.

Quick Overview for NHEJ1 antibody (AA 1-273) (Fluoro550) (ABIN8016092)

Target: NHEJ1 (Nonhomologous End-Joining Factor 1 (NHEJ1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NHEJ1 antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-NHEJ1 Antibody (Fluoro550)

Binding Specificity: AA 1-273

Purpose: Anti-XLF/NHEJ1 Antibody Fluoro550 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human XLF/NHEJ1 recombinant protein (Position: M1-E273).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for NHEJ1

Target: NHEJ1 (Nonhomologous End-Joining Factor 1 (NHEJ1))

Alternative Name: NHEJ1

Background:

Background: Non-homologous end-joining factor 1 (NHEJ1), also known as Cernunnos or XRCC4-like factor (XLF), is a protein that in humans is encoded by the NHEJ1 gene. It is mapped to 2q35. Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders.

Gene Full Name: non-homologous end joining factor 1

Gene ID: 79840

UniProt: Q9H9Q4

Pathways: DNA Damage Repair