NUP98 antibody (AA 728-1787) (Fluoro594)

Catalog No. ABIN8017436

This Rabbit Polyclonal antibody specifically detects NUP98 in FACS. It exhibits reactivity toward Human, Mouse, Rat and Monkey.

Quick Overview for NUP98 antibody (AA 728-1787) (Fluoro594) (ABIN8017436)

Target: NUP98 (Nucleoporin 98kDa (NUP98))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUP98 antibody is conjugated to Fluoro594

Application: Flow Cytometry (FACS)

Product Details anti-NUP98 Antibody (Fluoro594)

Binding Specificity: AA 728-1787

Purpose: Anti-NUP98 Antibody Fluoro594 Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human NUP98 shares 89.1%,89% amino acid (aa) sequence identity with mouse,rat NUP98,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human NUP98 recombinant protein (Position: H728-I1787). Human NUP98 shares 89.1% and 89% amino acid (aa) sequence identity with mouse and rat NUP98, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for NUP98

Target: NUP98 (Nucleoporin 98kDa (NUP98))

Alternative Name: NUP98

Background:

Background: Nuclear pore complex protein Nup98-Nup96 is a protein that in humans is encoded by the NUP98 gene. This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. NUP98 is a peripheral nucleoporin located at both the cytoplasmic and nuclear sides of the central channel of the NPC. NUP98 phosphorylation is critical for NPC disassembly at the onset of mitosis. It also plays roles in gene expression, mitotic checkpoint, and pathogenesis. Ligand blot analysis suggested that NUP98 can function as a docking protein for cytosol-mediated docking of import substrates. In addition to that, NUP98 is a target of the vesicular stomatitis virus M protein-mediated inhibition of mRNA nuclear export.

Gene Full Name: nucleoporin 98 and 96 precursor

Gene ID: 4928

UniProt: P52948

Pathways: Stem Cell Maintenance, Protein targeting to Nucleus, SARS-CoV-2 Protein Interactome