NUMB antibody (AA 59-567) (Fluoro488)

Catalog No. ABIN8017786

The Fluoro488-conjugated Rabbit Polyclonal anti-NUMB antibody (ABIN8017786) specifically detects NUMB in FACS. The antibody is reactive with Human, Mouse, Rat and Monkey samples.

Quick Overview for NUMB antibody (AA 59-567) (Fluoro488) (ABIN8017786)

Target: NUMB (Numb Homolog (NUMB))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUMB antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-NUMB Antibody (Fluoro488)

Binding Specificity: AA 59-567

Purpose: Anti-NUMB Antibody Fluoro488 Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human NUMB shares 93.7% amino acid (aa) sequence identity with both mouse,rat NUMB.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human NUMB recombinant protein (Position: E59-A567). Human NUMB shares 93.7% amino acid (aa) sequence identity with both mouse and rat NUMB.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for NUMB

Target: NUMB (Numb Homolog (NUMB))

Alternative Name: NUMB

Background:

Background: Protein numb homolog is a protein that in humans is encoded by the NUMB gene. It is mapped to 14q24.2 to q24.3. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. The primary function of Numb in cell differentiation is as an inhibitor of Notch signaling which is essential for maintaining self-renewal potential in stem and progenitor cells. Numb also plays a crucial role in asymmetrical cell division during development, allowing for differential cell fate specification in the central and peripheral nervous systems. What's more, the numb gene protein product controls binary cell fate decisions in the peripheral and central nervous systems of both invertebrates and mammals during neurogenesis.

Gene Full Name: NUMB endocytic adaptor protein

Gene ID: 8650

UniProt: P49757

Pathways: Cell-Cell Junction Organization