Oncostatin M Receptor antibody (AA 673-968) (Cy3)

Catalog No. ABIN8018104

The Cy3-conjugated Rabbit Polyclonal anti-Oncostatin M Receptor antibody (ABIN8018104) specifically detects Oncostatin M Receptor in FACS. The antibody is reactive with Mouse and Rat samples.

Quick Overview for Oncostatin M Receptor antibody (AA 673-968) (Cy3) (ABIN8018104)

Target: Oncostatin M Receptor (OSMR)

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Oncostatin M Receptor antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-Oncostatin M Receptor Antibody (Cy3)

Binding Specificity: AA 673-968

Purpose: Anti-Osmr Antibody Cy3 Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Mouse Osmr shares 57.7%,86.9% amino acid (aa) sequence identity with human,rat Osmr,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Osmr recombinant protein (Position: E673-Q968). Mouse Osmr shares 57.7% and 86.9% amino acid (aa) sequence identity with human and rat Osmr, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Oncostatin M Receptor

Target: Oncostatin M Receptor (OSMR)

Alternative Name: Osmr

Background:

Background: Oncostatin-M specific receptor subunit beta also known as the Oncostatin M receptor (OSMR) , is one of the receptor proteins for oncostatin M, that in humans is encoded by the OSMR gene. Oncostatin M is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving members of the hematopoietin receptor superfamily. Many IL6 cytokines utilize gp130 as a common receptor subunit. OSM binds to the gp130 receptor subunit and, in association with leukemia inhibitory factor receptor, induces a proliferative response in permissive cells. Mosley et al. (1996) used degenerate PCR to clone a novel hematopoietin receptor which they called the oncostatin M-specific receptor beta subunit (OSMR-beta). Sequencing revealed that this gene encodes a 979-amino acid protein containing characteristic motifs of the hematopoietin receptor family.

Gene Full Name: oncostatin M receptor

Gene ID: 18414

UniProt: O70458

Pathways: JAK-STAT Signaling, Growth Factor Binding