Oncostatin M Receptor antibody (AA 673-968)

Catalog No. ABIN8018113

The Rabbit Polyclonal anti-Oncostatin M Receptor antibody (ABIN8018113) specifically detects Oncostatin M Receptor in WB, ELISA and FACS. The antibody is reactive with Mouse and Rat samples.

Quick Overview for Oncostatin M Receptor antibody (AA 673-968) (ABIN8018113)

Target: Oncostatin M Receptor (OSMR)

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Oncostatin M Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Grade: Carrier-free

Product Details anti-Oncostatin M Receptor Antibody

Binding Specificity: AA 673-968

Purpose: Anti-Osmr Antibody

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Mouse Osmr shares 57.7%,86.9% amino acid (aa) sequence identity with human,rat Osmr,respectively.

Characteristics: Anti-Osmr Antibody. Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Osmr recombinant protein (Position: E673-Q968). Mouse Osmr shares 57.7% and 86.9% amino acid (aa) sequence identity with human and rat Osmr, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Mouse, Rat Flow Cytometry (Fixed), 1-3 μg /1x10⁶ cells, Mouse ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Oncostatin M Receptor

Target: Oncostatin M Receptor (OSMR)

Alternative Name: Osmr

Background:

Background: Oncostatin-M specific receptor subunit beta also known as the Oncostatin M receptor (OSMR) , is one of the receptor proteins for oncostatin M, that in humans is encoded by the OSMR gene. Oncostatin M is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving members of the hematopoietin receptor superfamily. Many IL6 cytokines utilize gp130 as a common receptor subunit. OSM binds to the gp130 receptor subunit and, in association with leukemia inhibitory factor receptor, induces a proliferative response in permissive cells. Mosley et al. (1996) used degenerate PCR to clone a novel hematopoietin receptor which they called the oncostatin M-specific receptor beta subunit (OSMR-beta). Sequencing revealed that this gene encodes a 979-amino acid protein containing characteristic motifs of the hematopoietin receptor family.

Gene Full Name: oncostatin M receptor

Molecular Weight: 110,180 kDa

Gene ID: 18414

UniProt: O70458

Pathways: JAK-STAT Signaling, Growth Factor Binding