OTUB1 antibody (AA 10-271) (HRP)

Catalog No. ABIN8018662

The HRP-conjugated Rabbit Polyclonal anti-OTUB1 antibody (ABIN8018662) specifically detects OTUB1 in WB, IHC and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for OTUB1 antibody (AA 10-271) (HRP) (ABIN8018662)

Target: OTUB1 (OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OTUB1 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-OTUB1 Antibody (HRP)

Binding Specificity: AA 10-271

Purpose: Anti-OTUB1 Antibody HRP Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human OTUB1 shares 99.6% amino acid (aa) sequence identity with both mouse,rat OTUB1.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human OTUB1 recombinant protein (Position: K10-K271). Human OTUB1 shares 99.6% amino acid (aa) sequence identity with both mouse and rat OTUB1.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for OTUB1

Target: OTUB1 (OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1))

Alternative Name: OTUB1

Background:

Background: Ubiquitin thioesterase OTUB1 also known as otubain-1 is an enzyme that in humans is encoded by the OTUB1 gene. The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants.

Gene Full Name: OTU deubiquitinase, ubiquitin aldehyde binding 1

Gene ID: 55611

UniProt: Q96FW1