P-Cadherin antibody (AA 236-645) (Fluoro594)

Catalog No. ABIN8018924

This Rabbit Polyclonal antibody specifically detects P-Cadherin in FACS. It exhibits reactivity toward Human.

Quick Overview for P-Cadherin antibody (AA 236-645) (Fluoro594) (ABIN8018924)

Target: P-Cadherin (CDH3)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This P-Cadherin antibody is conjugated to Fluoro594

Application: Flow Cytometry (FACS)

Product Details anti-P-Cadherin Antibody (Fluoro594)

Binding Specificity: AA 236-645

Purpose: Anti-P cadherin/CDH3 Antibody Fluoro594 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human P cadherin/CDH3 recombinant protein (Position: Q236-E645).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for P-Cadherin

Target: P-Cadherin (CDH3)

Alternative Name: CDH3

Background:

Background: Cadherins, such as CDH3, are integral membrane glycoproteins responsible for calcium-dependent cell-cell adhesion. Cadherin-3 is a protein that in humans is encoded by the CDH3 gene. This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.

Gene Full Name: cadherin 3

Gene ID: 1001

UniProt: P22223