P-Cadherin antibody (AA 236-645)

Catalog No. ABIN8018930

This Rabbit Polyclonal antibody specifically detects P-Cadherin in WB, FACS, ELISA, IF and ICC. It exhibits reactivity toward Human.

Quick Overview for P-Cadherin antibody (AA 236-645) (ABIN8018930)

Target: P-Cadherin (CDH3)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This P-Cadherin antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Grade: Carrier-free

Product Details anti-P-Cadherin Antibody

Binding Specificity: AA 236-645

Purpose: Anti-P cadherin/CDH3 Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-P cadherin/CDH3 Antibody. Tested in ELISA, Flow Cytometry, ICC/IF, WB applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human P cadherin/CDH3 recombinant protein (Position: Q236-E645).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human Flow Cytometry(Fixed), 1-3 μg/1x10⁶ cells, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for P-Cadherin

Target: P-Cadherin (CDH3)

Alternative Name: CDH3

Background:

Background: Cadherins, such as CDH3, are integral membrane glycoproteins responsible for calcium-dependent cell-cell adhesion. Cadherin-3 is a protein that in humans is encoded by the CDH3 gene. This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.

Gene Full Name: cadherin 3

Molecular Weight: 120 kDa

Gene ID: 1001

UniProt: P22223