PER2 antibody (AA 13-330) (Fluoro488)

Catalog No. ABIN8020496

This Rabbit Polyclonal antibody specifically detects PER2 in FACS. It exhibits reactivity toward Human.

Quick Overview for PER2 antibody (AA 13-330) (Fluoro488) (ABIN8020496)

Target: PER2 (Period Circadian Protein 2 (PER2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PER2 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-PER2 Antibody (Fluoro488)

Binding Specificity: AA 13-330

Purpose: Anti-PER2 Antibody Fluoro488 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human PER2 shares 84%,83% amino acid (aa) sequence identity with mouse,rat PER2,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PER2 recombinant protein (Position: N13-K330). Human PER2 shares 84% and 83% amino acid (aa) sequence identity with mouse and rat PER2, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for PER2

Target: PER2 (Period Circadian Protein 2 (PER2))

Alternative Name: PER2

Background:

Background: The PER2 gene encodes the period circadian protein homolog 2 protein in humans. This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. PER2 is mapped to 2q37.3. It has been showed that PER2 can positively stimulate activity of the Bmal1-Npas2 transcription complex and, in turn, Npas2 transcriptionally regulates delta-aminolevulinate synthase. PER2 is involved in a negative-feedback loop that attenuates estrogen stimulation and links the circadian cycle to estrogen receptor signaling. The rhythmic levels of PER2 are critical for circadian oscillations in cells and intact organisms. What's more, the PER2 gene also functions in tumor suppression by regulating DNA damage-responsive pathways.

Gene Full Name: period circadian regulator 2

Sequence Similarities: Contains 1 PAC (PAS-associated C-terminal) domain.

Gene ID: 8864

UniProt: O15055