Peroxiredoxin 3 antibody (C-Term) (APC)

Catalog No. ABIN8020645

The APC-conjugated Rabbit Polyclonal anti-Peroxiredoxin 3 antibody (ABIN8020645) specifically detects Peroxiredoxin 3 in FACS. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for Peroxiredoxin 3 antibody (C-Term) (APC) (ABIN8020645)

Target: Peroxiredoxin 3 (PRDX3)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Peroxiredoxin 3 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-Peroxiredoxin 3 Antibody (APC)

Binding Specificity: C-Term

Purpose: Anti-Peroxiredoxin 3/PRDX3 Antibody APC Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: identical to the related rat sequence,and different from the related human sequence by three amino acids.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of mouse Peroxiredoxin 3, identical to the related rat sequence, and different from the related human sequence by three amino acids.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Peroxiredoxin 3

Target: Peroxiredoxin 3 (PRDX3)

Alternative Name: PRDX3

Background:

Background: PRDX3 (peroxiredoxin 3) also known as AOP-1, MER5, SP-22 or PRX3, is localized exclusively in mitochondria. The deduced 256-amino acid human AOP1 protein shares 86% amino acid sequence similarity with mouse Aop1, and significant similarity with both the human proliferation-associated gene A product and the mouse stress-induced peritoneal macrophage protein Msp23. The PRDX3 gene is mapped on 10q26.11. Expression of PRDX3 is induced by MYC and is reduced in c-myc -/- cells. Chromatin immunoprecipitation analysis spanning the entire PRDX3 genomic sequence revealed that MYC binds preferentially to a 930-bp region surrounding exon 1. Results using mitochondria-specific fluorescent probes demonstrated that PRDX3 is essential for maintaining mitochondrial mass and membrane potential in transformed rat and human cells. These data provided evidence that PRDX3 is a MYC target gene that is required to maintain normal mitochondrial function.

Gene Full Name: peroxiredoxin 3

Sequence Similarities: Belongs to the AhpC/TSA family.

Gene ID: 11757

UniProt: P20108

Pathways: Ribonucleoside Biosynthetic Process, Methionine Biosynthetic Process