PIK3C2A antibody (AA 22-1523) (PE)

Catalog No. ABIN8021898

The Rabbit Polyclonal anti-PIK3C2A antibody is suitable to detect PIK3C2A in samples from Human and Mouse. It has been validated for FACS.

Quick Overview for PIK3C2A antibody (AA 22-1523) (PE) (ABIN8021898)

Target: PIK3C2A (Phosphoinositide-3-Kinase, Class 2, alpha Polypeptide (PIK3C2A))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIK3C2A antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-PIK3C2A Antibody (PE)

Binding Specificity: AA 22-1523

Purpose: Anti-PIK3C2A Antibody PE Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human PIK3C2A shares 89.7% amino acid (aa) sequence identity with mouse PIK3C2A.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PIK3C2A recombinant protein (Position: R22-E1523). Human PIK3C2A shares 89.7% amino acid (aa) sequence identity with mouse PIK3C2A.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for PIK3C2A

Target: PIK3C2A (Phosphoinositide-3-Kinase, Class 2, alpha Polypeptide (PIK3C2A))

Alternative Name: PIK3C2A

Background:

Background: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.

Gene Full Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

Gene ID: 5286

UniProt: O00443

Pathways: EGFR Signaling Pathway, Inositol Metabolic Process, Platelet-derived growth Factor Receptor Signaling