PNN antibody (AA 2-241) (HRP)

Catalog No. ABIN8022596

This Rabbit Polyclonal antibody specifically detects PNN in WB, ELISA and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PNN antibody (AA 2-241) (HRP) (ABIN8022596)

Target: PNN (Pinin, Desmosome Associated Protein (PNN))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PNN antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-PNN Antibody (HRP)

Binding Specificity: AA 2-241

Purpose: Anti-PNN/DRSP Antibody HRP Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PNN/DRSP recombinant protein (Position: A2-L241).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PNN

Target: PNN (Pinin, Desmosome Associated Protein (PNN))

Alternative Name: PNN

Background:

Background: Pinin is a protein that in humans is encoded by the PNN gene. By yeast 2-hybrid analysis of HeLa cells, followed by sequence analysis, it was found that epitope-tagged human PNN interacted with the serine/arginine (SR)-rich proteins SRP75 (SRSF4, 601940), SRM300 (SRRM2, 606032), and SRRP130 (PNISR, 616653). Truncation analysis revealed that the polyserine/RS domain of PNN and flanking sequences participated in binding to these SR proteins. The 4 proteins colocalized in the nucleus of HCE-T cells, and overexpression of any of these proteins affected the distribution of the others between nuclear speckles and nucleoplasm.

Gene Full Name: pinin, desmosome associated protein

Gene ID: 5411

UniProt: Q9H307