Plakophilin 2 antibody (AA 369-804) (PE)

Catalog No. ABIN8022787

The PE-conjugated Rabbit Polyclonal anti-Plakophilin 2 antibody (ABIN8022787) specifically detects Plakophilin 2 in FACS. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for Plakophilin 2 antibody (AA 369-804) (PE) (ABIN8022787)

Target: Plakophilin 2 (PKP2)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Plakophilin 2 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-Plakophilin 2 Antibody (PE)

Binding Specificity: AA 369-804

Purpose: Anti-PKP2 Antibody PE Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human PKP2 shares 82.8%,79.4% amino acid (aa) sequence identity with mouse,rat PKP2,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PKP2 recombinant protein (Position: R369-Q804). Human PKP2 shares 82.8% and 79.4% amino acid (aa) sequence identity with mouse and rat PKP2, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Plakophilin 2

Target: Plakophilin 2 (PKP2)

Alternative Name: PKP2

Background:

Background: Plakophilin-2 is a protein that in humans is encoded by the PKP2 gene. This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene may regulate the signaling activity of beta-catenin and is required to maintain transcription of genes that control intracellular calcium cycling including ryanodine receptor 2, ankyrin-B, triadin, and calcium channel, voltage-dependent, L type, alpha 1C. Mutations in this gene are associated with different inherited cardiac conditions including Arrythmogenic Cardiomyopathy, Brugada Syndrome, and Idiopathic Ventricular Fibrillation. A processed pseudogene with high similarity to this gene has been mapped to chromosome 12p13.

Gene Full Name: plakophilin 2

Gene ID: 5318

UniProt: Q99959

Pathways: Cell-Cell Junction Organization, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection