PARN antibody (AA 1-301) (APC)

Catalog No. ABIN8023905

The Rabbit Polyclonal anti-PARN antibody is suitable to detect PARN in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for PARN antibody (AA 1-301) (APC) (ABIN8023905)

Target: PARN (Poly A Specific Ribonuclease (PARN))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARN antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-PARN Antibody (APC)

Binding Specificity: AA 1-301

Purpose: Anti-PARN Antibody APC Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human PARN recombinant protein (Position: M1-Y301).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for PARN

Target: PARN (Poly A Specific Ribonuclease (PARN))

Alternative Name: PARN

Background:

Background: Poly (A)-specific ribonuclease (PARN), also known as polyadenylate-specific ribonuclease or deadenylating nuclease (DAN), is an enzyme that in humans is encoded by the PARN gene. The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly (A) as the substrate, hence, efficiently degrades poly (A) tails of mRNAs. Exonucleolytic degradation of the poly (A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons.

Gene Full Name: poly(A)-specific ribonuclease

Gene ID: 5073

UniProt: O95453