POT1 antibody (N-Term) (Fluoro550)

Catalog No. ABIN8027028

The Rabbit Polyclonal anti-POT1 antibody is suitable to detect POT1 in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for POT1 antibody (N-Term) (Fluoro550) (ABIN8027028)

Target: POT1 (Protection of Telomeres 1 (POT1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POT1 antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-POT1 Antibody (Fluoro550)

Binding Specificity: N-Term

Purpose: Anti-POT1 Antibody Fluoro550 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: different from the related mouse sequence by eleven amino acids.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human POT1, different from the related mouse sequence by eleven amino acids.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for POT1

Target: POT1 (Protection of Telomeres 1 (POT1))

Alternative Name: POT1

Background:

Background: Protection of telomeres protein 1 is a protein that in humans is encoded by the POT1 gene. This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.

Gene Full Name: protection of telomeres 1

Gene ID: 25913

UniProt: Q9NUX5

Pathways: Cell Division Cycle, Telomere Maintenance