POT1 antibody (AA 15-638) (Fluoro594)

Catalog No. ABIN8027040

The Rabbit Polyclonal anti-POT1 antibody is suitable to detect POT1 in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for POT1 antibody (AA 15-638) (Fluoro594) (ABIN8027040)

Target: POT1 (Protection of Telomeres 1 (POT1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POT1 antibody is conjugated to Fluoro594

Application: Flow Cytometry (FACS)

Product Details anti-POT1 Antibody (Fluoro594)

Binding Specificity: AA 15-638

Purpose: Anti-POT1 Antibody Fluoro594 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived rat POT1 recombinant protein (Position: N15-V638).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for POT1

Target: POT1 (Protection of Telomeres 1 (POT1))

Alternative Name: Pot1

Background:

Background: Protection of telomeres protein 1 is a protein that in humans is encoded by the POT1 gene. This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.

Gene Full Name: protection of telomeres 1

Gene ID: 500054

Pathways: Cell Division Cycle, Telomere Maintenance