PNP antibody (Middle Region) (APC)

Catalog No. ABIN8028963

The Mouse Monoclonal anti-PNP antibody is suitable to detect PNP in samples from Human and Rat. It has been validated for FACS.

Quick Overview for PNP antibody (Middle Region) (APC) (ABIN8028963)

Target: PNP (Purine Nucleoside Phosphorylase (PNP))

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This PNP antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Clone: 2H10

Product Details anti-PNP Antibody (APC)

Binding Specificity: Middle Region

Purpose: Anti-PNP Antibody (monoclonal, 2H10) APC Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: different from the related mouse sequence by six amino acids,and from the related rat sequence by five amino acids.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human PNP, different from the related mouse sequence by six amino acids, and from the related rat sequence by five amino acids.

Isotype: IgG2b

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for PNP

Target: PNP (Purine Nucleoside Phosphorylase (PNP))

Alternative Name: PNP

Background:

Background: The PNP gene encodes purine nucleoside phosphorylase, an enzyme that catalyzes the reversible phosphorolysis of the purine nucleosides and deoxynucleosides inosine, guanosine, deoxyinosine, and deoxyguanosine. It is presented results from gene dosage studies consistent with assignment of the PNP locus to band 14q13. PNP is expressed in most tissues, with markedly greater expression in lymphoid tissues. Genetic deficiencies of PNP result in severely compromised Tlymphocyte function and neurologic dysfunction.

Gene Full Name: purine nucleoside phosphorylase

Gene ID: 4860

UniProt: P00491

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Ribonucleoside Biosynthetic Process, Positive Regulation of Response to DNA Damage Stimulus